Organic disulfides
Medchemexpress LLC PROTAC degrader targeting Bruton's tyrosine kinase (BTK) | 2416131-46-7 | 99.7% | 719.83 | C39H45N9O5 | 10 MG
NX-2127 is an orally bioavailable PROTAC degrader that targets Bruton's tyrosine kinase (BTK). It induces proteasomal degradation of BTK, shows activity against BTK C481S resistance mutants, degrades IKZF1 and IKZF3 transcription factors, and has demonstrated cellular and in vivo preclinical activity while promoting T cell activation and IL-2 production.
- Orally bioavailable PROTAC degrader of BTK.
- Induces proteasomal degradation of BTK and reduces BTK signaling.
- Active against BTK C481S resistance mutants in cellular models.
- Degrades IKZF1 and IKZF3, providing immunomodulatory effects.
- Stimulates T cell activation and increases IL-2 production in primary human T cells.
- Demonstrated efficacy in preclinical in vivo models.
Chem-Impex International, Inc. 3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester | 68181-17-9 | MFCD00009636 | 100MG
3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester, 68181-17-9, MFCD00009636, 100MG
Medchemexpress LLC (R)-NX-2127 | 3024312-52-2 | 98.9% | 719.83 | C39H45N9O5 | 10 MG
(R)-NX-2127 is the R-isomer of a Bruton's tyrosine kinase (BTK) PROTAC degrader supplied as a high-purity solid for preclinical research. The compound is intended for use in studies of BTK degradation and related cellular pharmacology; consult the supplier product page and SDS for handling and storage details.
- R-isomer of a BTK PROTAC degrader
- High reported purity (98.93%)
- Molecular weight 719.83
- Chemical formula C39H45N9O5
- Solid, light yellow to yellow appearance
- Recommended storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month)
- Intended for preclinical BTK degradation and cellular assays
Medchemexpress LLC N N-Dicyclohexyl-2-b 100g
N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats
Medchemexpress LLC Hydroxyethyl disulfide | 1892-29-1 | MFCD00002906 | 98.8% | 154.25 g/mol | C4H10O2S2 | 10 G
Hydroxyethyl disulfide is a small-molecule laboratory reagent used in biochemical research. It is reported to interact with thymidylate synthase pathways and is provided with supporting documentation such as a certificate of analysis and safety data sheet. The compound is commonly used as a reagent or intermediate in chemical and biochemical studies.
- Purity 98.8% (reported)
- Cas number 1892-29-1
- Molecular formula C4H10O2S2
- Molecular weight 154.25 g/mol
- Available as a 10 G package
Medchemexpress LLC N N-Dicyclohexyl-2-b 25g
N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats
eMolecules Ambeed / 2-(4-Nitrobenzamido)acetic acid / 1g / 586036432 / A703345 / / 2645-07-0 / MFCD00007349 / 224.172 / C9H8N2O5
Ambeed / 2-(4-Nitrobenzamido)acetic acid / 1g / 586036432 / A703345 / / 2645-07-0 / MFCD00007349 / 224.172 / C9H8N2O5